产品货号：
Z12033
中文名称：
BRCC36/BRCC3抗体
英文名称：
Anti-BRCC36/BRCC3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BRCC36/BRCC3 Antibody |
| 指标别名 | BRCA1 A complex subunit BRCC36;BRCC3;BRCC36;BRISC complex subunit BRCC36;C6.1A;CXorf53 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | BRCC3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | BRCC36 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC36.The immunogen is located within amino acids 20 - 70 of BRCC36. |
| 计算分子量 | 36kDa |
| 成分 | BRCC36 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | BRCC36 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45,BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity.Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint,indicating that BRCC36 acts to enhance cellular survival following DNA damage.Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation,suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors.At least two isoforms of BRCC36 are known to exist. |
| Uniprot ID | P46736 |
| 基因名全称 | BRCA1/BRCA2-containing complex,subunit 3 |
| 蛋白名全称 | BRCA1/BRCA2-containing complex,subunit 3 |
| 推荐稀释比 | BRCC36 antibody can be used for detection of BRCC36 by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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